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http://purl.uniprot.org/citations/33966694http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33966694http://www.w3.org/2000/01/rdf-schema#comment"Objective To investigate the expression of Cripto-1 in pancreatic cancer and to analyze its clinical significance. Methods Cripto-1 expression in normal pancreas,pancreatic cancer and adjacent non-tumor tissues,chronic pancreatitis tissues and other related tissues was evaluated using immunohistochemistry.The association of Cripto-1 expression with the clinicopathological characteristics and the prognostic value of Cripto-1 in patients with pancreatic cancer were analyzed. Results The expression of Cripto-1 was higher in chronic pancreatitis tissues,pancreatic cancer and its metastases than in normal pancreas(P=0.019,P=0.025,and P=0.018,respectively).Cripto-1 overexpression was correlated with poorly differentiated pancreatic cancer.The patients with Cripto-1 upregulation had shorter median survival time(8 months vs.16 months,χ 2=4.787,P=0.029).However,multivariate analysis failed to demonstrate overexpression of Cripto-1 an independent prognostic indicator in patients with pancreatic cancer(HR=1.341,95% CI=0.800-2.248,P=0.266).Conclusions Cripto-1 may play an important role in the development and progression of pancreatic cancer.It can be a potential prognostic biomarker for patients with pancreatic cancer."xsd:string
http://purl.uniprot.org/citations/33966694http://purl.org/dc/terms/identifier"doi:10.3881/j.issn.1000-503x.12734"xsd:string
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/author"Gao X."xsd:string
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/author"Lu T."xsd:string
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/author"Xu Q."xsd:string
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/author"Liao Q."xsd:string
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/author"Zhang R.H."xsd:string
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/author"Pan B.J."xsd:string
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/name"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"xsd:string
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/pages"173-179"xsd:string
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/title"[Expression and Prognostic Value of Cripto-1 in Pancreatic Cancer]."xsd:string
http://purl.uniprot.org/citations/33966694http://purl.uniprot.org/core/volume"43"xsd:string
http://purl.uniprot.org/citations/33966694http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33966694
http://purl.uniprot.org/citations/33966694http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33966694
http://purl.uniprot.org/uniprot/#_B2R8C7-mappedCitation-33966694http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33966694
http://purl.uniprot.org/uniprot/#_F5H1T8-mappedCitation-33966694http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33966694
http://purl.uniprot.org/uniprot/#_P13385-mappedCitation-33966694http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33966694
http://purl.uniprot.org/uniprot/B2R8C7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33966694
http://purl.uniprot.org/uniprot/P13385http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33966694
http://purl.uniprot.org/uniprot/F5H1T8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33966694