| http://purl.uniprot.org/citations/33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33972599 | http://www.w3.org/2000/01/rdf-schema#comment | "Much in vivo evidence indicates that cyclooxygenase-2 (COX-2) is deeply involved in tumorigenesis. Although it has been proposed that COX-2-derived pro-inflammatory prostanoids mediate the tumorigenic activity of COX-2, the tumorigenic mechanisms of COX-2 are not yet fully understood. Here, we investigated the mechanism by which COX-2 causes transformation from normal cells to malignant cells by using normal murine or human cells. We found that COX-2 inhibits the pro-senescent function of p53 under oncogenic RAS activation, by which it prevents oncogene-induced senescence (OIS) and induces neoplastic transformation. We also found that COX-2 physically interacts with p53 in the nucleus under oncogenic RAS activation, and that this COX-2-p53 interaction rather than the catalytic activity is involved in the COX-2-mediated inhibition of the pro-senescent function of p53 and OIS, and induction of neoplastic transformation. These findings strongly suggest that the oncogenic property of COX-2 is closely related to its ability to inactivate p53 under strong mitogenic signals, and that aberrant activation of the COX-2/a mitogenic oncogene combination can be a potent driving force for tumorigenesis. This study might contribute to our understanding of the molecular basis for the tumorigenic activity of COX-2 and the development of novel anti-tumor drugs targeting COX-2-p53 interactions."xsd:string |
| http://purl.uniprot.org/citations/33972599 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-021-89220-5"xsd:string |
| http://purl.uniprot.org/citations/33972599 | http://purl.uniprot.org/core/author | "Lee H.J."xsd:string |
| http://purl.uniprot.org/citations/33972599 | http://purl.uniprot.org/core/author | "Jung Y.J."xsd:string |
| http://purl.uniprot.org/citations/33972599 | http://purl.uniprot.org/core/author | "Kim S.R."xsd:string |
| http://purl.uniprot.org/citations/33972599 | http://purl.uniprot.org/core/author | "Han J.A."xsd:string |
| http://purl.uniprot.org/citations/33972599 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33972599 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/33972599 | http://purl.uniprot.org/core/pages | "9853"xsd:string |
| http://purl.uniprot.org/citations/33972599 | http://purl.uniprot.org/core/title | "Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence."xsd:string |
| http://purl.uniprot.org/citations/33972599 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33972599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33972599 |
| http://purl.uniprot.org/citations/33972599 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33972599 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |
| http://purl.uniprot.org/uniprot/#_D9MWI3-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |
| http://purl.uniprot.org/uniprot/#_A0A346XLS5-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |
| http://purl.uniprot.org/uniprot/#_A0A346XLT4-mappedCitation-33972599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972599 |