| http://purl.uniprot.org/citations/33972729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33972729 | http://www.w3.org/2000/01/rdf-schema#comment | "Coordination of stem cell function by local and niche-derived signals is essential to preserve adult tissue homeostasis and organismal health. The vasculature is a prominent component of multiple stem cell niches. However, its role in adult intestinal homeostasis remains largely understudied. Here we uncover a previously unrecognised crosstalk between adult intestinal stem cells in Drosophila and the vasculature-like tracheal system, which is essential for intestinal regeneration. Following damage to the intestinal epithelium, gut-derived reactive oxygen species activate tracheal HIF-1α and bidirectional FGF/FGFR signalling, leading to reversible remodelling of gut-associated terminal tracheal cells and intestinal stem cell proliferation following damage. Unexpectedly, reactive oxygen species-induced adult tracheal plasticity involves downregulation of the tracheal specification factor trachealess (trh) and upregulation of IGF2 messenger RNA-binding protein (IGF2BP2/Imp). Our results reveal an intestine-vasculature inter-organ communication programme that is essential to adapt the stem cell response to the proliferative demands of the intestinal epithelium."xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41556-021-00676-z"xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/author | "Perochon J."xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/author | "Cordero J.B."xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/author | "Southall T.D."xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/author | "Aughey G.N."xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/author | "Medina A.B."xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/pages | "485-496"xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/title | "Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/33972729 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33972729 |
| http://purl.uniprot.org/citations/33972729 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33972729 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHI3-mappedCitation-33972729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972729 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LIX2-mappedCitation-33972729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972729 |
| http://purl.uniprot.org/uniprot/#_B7Z0S3-mappedCitation-33972729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972729 |
| http://purl.uniprot.org/uniprot/#_E1JJM0-mappedCitation-33972729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972729 |
| http://purl.uniprot.org/uniprot/#_M9NF14-mappedCitation-33972729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972729 |
| http://purl.uniprot.org/uniprot/#_Q09147-mappedCitation-33972729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972729 |
| http://purl.uniprot.org/uniprot/#_M9PBG9-mappedCitation-33972729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972729 |
| http://purl.uniprot.org/uniprot/#_Q24119-mappedCitation-33972729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972729 |
| http://purl.uniprot.org/uniprot/#_Q24167-mappedCitation-33972729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33972729 |