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http://purl.uniprot.org/citations/33978159http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objectives

To evaluate SATB2 expression and prognostic implications in a large cohort of thoracic neuroendocrine tumors.

Methods

Surgical pathology files (1995-2017) and an institutional thymic epithelial tumor database (2010-2020) were searched for resected neuroendocrine tumors. Cases were stained with SATB2 (clone EP281). Percent SATB2-positive tumor cells and expression intensity were scored.

Results

In the lung, SATB2 was expressed in 5% or more of tumor cells in 29 (74.4%) of 39 small cell carcinomas and 9 (22.5%) of 40 atypical and 26 (40.6%) of 64 typical carcinoid tumors. SATB2 percent tumor cell expression and intensity were higher in small cell carcinomas than in carcinoid tumors (both P < .001, respectively). After adjusting for tumor subtype, SATB2 expression did not correlate with outcome. In the thymus, four (100%) of four atypical carcinoid tumors and one large cell neuroendocrine carcinoma but no small cell carcinoma (n = 2) expressed SATB2 in 5% or more of tumor cells.

Conclusions

SATB2 (clone EP281) is expressed in a large subset of pulmonary and thymic neuroendocrine tumors and therefore does not appear to be a useful marker to identify the origin of neuroendocrine tumors. Validation studies are needed, specifically including thymic neuroendocrine tumors, as the expression pattern might be different in those tumors."xsd:string
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http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/author"Xie H."xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/author"Vrana J.A."xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/author"Jenkins S.M."xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/author"Molina J.R."xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/author"Boland J.M."xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/author"Mansfield A.S."xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/author"Roden A.C."xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/author"Terra S.B.S.P."xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/author"Cassivi S.D."xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/name"Am J Clin Pathol"xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/pages"853-865"xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/title"SATB2 Is Expressed in a Subset of Pulmonary and Thymic Neuroendocrine Tumors."xsd:string
http://purl.uniprot.org/citations/33978159http://purl.uniprot.org/core/volume"156"xsd:string
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