| http://purl.uniprot.org/citations/33980692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33980692 | http://www.w3.org/2000/01/rdf-schema#comment | "Pancreatic β-cell mass and insulin secretion are determined by the dynamic change of transcription factor expression levels in response to altered metabolic demand. Nuclear factor-Y (NF-Y) is an evolutionarily conserved transcription factor playing critical roles in multiple cellular processes. However, the physiological role of NF-Y in pancreatic β-cells is poorly understood. The current study was undertaken in a conditional knockout of Nf-ya specifically in pancreatic β-cells (Nf-ya βKO) to define the essential physiological role of NF-Y in β-cells. Nf-ya βKO mice exhibited glucose intolerance without changes in insulin sensitivity. Reduced β-cell proliferation resulting in decreased β-cell mass was observed in these mice, which was associated with disturbed actin cytoskeleton. NF-Y-deficient β-cells also exhibited impaired insulin secretion with a reduced Ca2+ influx in response to glucose, which was associated with an inefficient glucose uptake into β-cells due to a decreased expression of GLUT2 and a reduction in ATP production resulting from the disruption of mitochondrial integrity. This study is the first to show that NF-Y is critical for pancreatic islet homeostasis and function through regulation in β-cell proliferation, glucose uptake into β-cells, and mitochondrial energy metabolism. Modulating NF-Y expression in β-cells may therefore offer an attractive approach for therapeutic intervention."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.org/dc/terms/identifier | "doi:10.2337/db20-1238"xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/author | "He S."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/author | "Su Z."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/author | "Zhou R."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/author | "Deng D."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/pages | "1703-1716"xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/title | "Nuclear Factor-Y in Mouse Pancreatic beta-Cells Plays a Crucial Role in Glucose Homeostasis by Regulating beta-Cell Mass and Insulin Secretion."xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/33980692 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33980692 |
| http://purl.uniprot.org/citations/33980692 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33980692 |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J1Y8-mappedCitation-33980692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33980692 |
| http://purl.uniprot.org/uniprot/#_E9Q7Z0-mappedCitation-33980692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33980692 |