| http://purl.uniprot.org/citations/33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33989401 | http://www.w3.org/2000/01/rdf-schema#comment | "Changes in gene regulation at multiple levels may comprise an important share of the molecular changes underlying adaptive evolution in nature. However, few studies have assayed within- and between-population variation in gene regulatory traits at a transcriptomic scale, and therefore inferences about the characteristics of adaptive regulatory changes have been elusive. Here, we assess quantitative trait differentiation in gene expression levels and alternative splicing (intron usage) between three closely related pairs of natural populations of Drosophila melanogaster from contrasting thermal environments that reflect three separate instances of cold tolerance evolution. The cold-adapted populations were known to show population genetic evidence for parallel evolution at the SNP level, and here we find evidence for parallel expression evolution between them, with stronger parallelism at larval and adult stages than for pupae. We also implement a flexible method to estimate cis-vs trans-encoded contributions to expression or splicing differences at the adult stage. The apparent contributions of cis-vs trans-regulation to adaptive evolution vary substantially among population pairs. While two of three population pairs show a greater enrichment of cis-regulatory differences among adaptation candidates, trans-regulatory differences are more likely to be implicated in parallel expression changes between population pairs. Genes with significant cis-effects are enriched for signals of elevated genetic differentiation between cold- and warm-adapted populations, suggesting that they are potential targets of local adaptation. These findings expand our knowledge of adaptive gene regulatory evolution and our ability to make inferences about this important and widespread process."xsd:string |
| http://purl.uniprot.org/citations/33989401 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/iyab077"xsd:string |
| http://purl.uniprot.org/citations/33989401 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/33989401 | http://purl.uniprot.org/core/author | "Pool J.E."xsd:string |
| http://purl.uniprot.org/citations/33989401 | http://purl.uniprot.org/core/author | "Lack J.B."xsd:string |
| http://purl.uniprot.org/citations/33989401 | http://purl.uniprot.org/core/author | "Hoppel G.T."xsd:string |
| http://purl.uniprot.org/citations/33989401 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33989401 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/33989401 | http://purl.uniprot.org/core/pages | "iyab077"xsd:string |
| http://purl.uniprot.org/citations/33989401 | http://purl.uniprot.org/core/title | "Parallel and population-specific gene regulatory evolution in cold-adapted fly populations."xsd:string |
| http://purl.uniprot.org/citations/33989401 | http://purl.uniprot.org/core/volume | "218"xsd:string |
| http://purl.uniprot.org/citations/33989401 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33989401 |
| http://purl.uniprot.org/citations/33989401 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33989401 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEY8-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LF54-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6K9-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7Y7-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JDC8-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LGH5-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |
| http://purl.uniprot.org/uniprot/#_A0A6F7R657-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |
| http://purl.uniprot.org/uniprot/#_A0A1Z1CK36-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |
| http://purl.uniprot.org/uniprot/#_A8JNJ6-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |
| http://purl.uniprot.org/uniprot/#_A8JQX3-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |
| http://purl.uniprot.org/uniprot/#_B7Z134-mappedCitation-33989401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33989401 |