| http://purl.uniprot.org/citations/33995349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33995349 | http://www.w3.org/2000/01/rdf-schema#comment | "Desmogleins are involved in cell adhesion conferring structural skin integrity. However, their role in inflammation has been barely studied, and whether desmoglein-4 modulates psoriasis lesions is completely unknown. In this study, we assessed the impact of desmoglein-4 deficiency on the severity of imiquimod (IMQ)-induced skin inflammation and psoriasiform lesions. To this end, desmoglein-4-/- Oncins France Colony A (OFA) with Sprague-Dawley (SD) genetic background were used. Additionally, human RNA-Seq datasets from psoriasis (PSO), atopic dermatitis (AD), and a healthy cohort were analyzed to obtain a desmosome gene expression overview. OFA rats displayed an intense skin inflammation while SD showed only mild inflammatory changes after IMQ treatment. We found that IMQ treatment increased CD3+ T cells in skin from both OFA and SD, being higher in desmoglein-4-deficient rats. In-depth transcriptomic analysis determined that PSO displayed twofold less DSG4 expression than healthy samples while both, PSO and AD showed more than three-fold change expression of DSG3 and DSC2 genes. Although underlying mechanisms are still unknown, these results suggest that the lack of desmoglein-4 may contribute to immune-mediated skin disease progression, promoting leukocyte recruitment to skin. Although further research is needed, targeting desmoglein-4 could have a potential impact on designing new biomarkers for skin diseases."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2021.625617"xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Sanchez M.B."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Neira F.J."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Pietrobon E.O."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Valdez S.R."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Jahn G.A."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Mackern-Oberti J.P."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Cargnelutti D.E."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Fernandez-Munoz J.M."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Zoppino F.C.M."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Germano M.J."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Innocenti A.C."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/author | "Moreno-Sosa T."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/pages | "625617"xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/title | "Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4."xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33995349 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33995349 |
| http://purl.uniprot.org/citations/33995349 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33995349 |
| http://purl.uniprot.org/uniprot/#_A6J2F7-mappedCitation-33995349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33995349 |
| http://purl.uniprot.org/uniprot/#_Q86SJ6-mappedCitation-33995349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33995349 |
| http://purl.uniprot.org/uniprot/#_Q6W3B0-mappedCitation-33995349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33995349 |