| http://purl.uniprot.org/citations/34006859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34006859 | http://www.w3.org/2000/01/rdf-schema#comment | "The impact of immune mediators on weight homeostasis remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative regulator of Toll-like receptor signaling serendipitously uncovered a role for B cell activating factor (BAFF). Here we show that overexpression of BAFF in multiple mouse models associates with protection from weight gain, approximating a log-linear dose response relation to BAFF concentrations. Gene expression analysis of BAFF-stimulated subcutaneous white adipocytes unveils upregulation of lipid metabolism pathways, with BAFF inducing white adipose tissue (WAT) lipolysis. Brown adipose tissue (BAT) from BAFF-overexpressing mice exhibits increased Ucp1 expression and BAFF promotes brown adipocyte respiration and in vivo energy expenditure. A proliferation-inducing ligand (APRIL), a BAFF homolog, similarly modulates WAT and BAT lipid handling. Genetic deletion of both BAFF and APRIL augments diet-induced obesity. Lastly, BAFF/APRIL effects are conserved in human adipocytes and higher BAFF/APRIL levels correlate with greater BMI decrease after bariatric surgery. Together, the BAFF/APRIL axis is a multifaceted immune regulator of weight gain and adipose tissue function."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-23084-1"xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Relman D.A."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Mukherjee R."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Chan C.C."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Allen J.L."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Karp C.L."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Flick M.J."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Seeley R.J."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Sanchez-Gurmaches J."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Pamp S.J."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Pfluger P.T."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Tschop M.H."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Harley I.T.W."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Trompette A."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Inge T.H."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Flick L.M."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Divanovic S."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Weisberg S.P."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Karns R."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Moreno-Fernandez M.E."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Stankiewicz T.E."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Helmrath M."xsd:string |
| http://purl.uniprot.org/citations/34006859 | http://purl.uniprot.org/core/author | "Damen M.S.M.A."xsd:string |