| http://purl.uniprot.org/citations/34014841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34014841 | http://www.w3.org/2000/01/rdf-schema#comment | "Cigarette smoke (CS) is the main etiological factor in the pathogenesis of emphysema/chronic obstructive pulmonary disease (COPD), which is associated with abnormal epithelial-mesenchymal transition (EMT). Previously, we have shown an association among circadian rhythms, CS-induced lung inflammation, and nuclear heme receptor α (REV-ERBα), acting as an antiinflammatory target in both pulmonary epithelial cells and fibroblasts. We hypothesized that molecular clock REV-ERBα plays an important role in CS-induced circadian dysfunction and EMT alteration. C57BL/6J WT and REV-ERBα heterozygous (Het) and -KO mice were exposed to CS for 30 days (subchronic) and 4 months (chronic), and WT mice were exposed to CS for 10 days with or without REV-ERBα agonist (SR9009) administration. Subchronic/chronic CS exposure caused circadian disruption and dysregulated EMT in the lungs of WT and REV-ERBα-KO mice; both circadian and EMT dysregulation were exaggerated in the REV-ERBα-KO condition. REV-ERBα agonist, SR9009 treatment reduced acute CS-induced inflammatory response and abnormal EMT in the lungs. Moreover, REV-ERBα agonist (GSK4112) inhibited TGF-β/CS-induced fibroblast differentiation in human fetal lung fibroblast 1 (HFL-1). Thus, CS-induced circadian gene alterations and EMT activation are mediated through a Rev-erbα-dependent mechanism, which suggests activation of REV-ERBα as a novel therapeutic approach for smoking-induced chronic inflammatory lung diseases."xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.145200"xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://purl.uniprot.org/core/author | "Rahman I."xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://purl.uniprot.org/core/author | "Sundar I.K."xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://purl.uniprot.org/core/author | "Lucas J.H."xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://purl.uniprot.org/core/author | "Muthumalage T."xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34014841 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://purl.uniprot.org/core/pages | "145200"xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://purl.uniprot.org/core/title | "Molecular clock REV-ERBalpha regulates cigarette smoke-induced pulmonary inflammation and epithelial-mesenchymal transition."xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/34014841 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34014841 |
| http://purl.uniprot.org/citations/34014841 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34014841 |
| http://purl.uniprot.org/uniprot/#_Q3UV55-mappedCitation-34014841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34014841 |
| http://purl.uniprot.org/uniprot/Q3UV55 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34014841 |