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http://purl.uniprot.org/citations/34017337http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34017337http://www.w3.org/2000/01/rdf-schema#comment"HLA-B*13:01 allele has been identified as the genetic determinant of dapsone hypersensitivity syndrome (DHS) among leprosy and non-leprosy patients in several studies. Dapsone hydroxylamine (DDS-NHOH), an active metabolite of dapsone, has been believed to be responsible for DHS. However, studies have not highlighted the importance of other genetic polymorphisms in dapsone-induced severe cutaneous adverse reactions (SCAR). We investigated the association of HLA alleles and cytochrome P450 (CYP) alleles with dapsone-induced SCAR in Thai non-leprosy patients. A prospective cohort study, 16 Thai patients of dapsone-induced SCARs (5 SJS-TEN and 11 DRESS) and 9 Taiwanese patients of dapsone-induced SCARs (2 SJS-TEN and 7 DRESS), 40 dapsone-tolerant controls, and 470 general Thai population were enrolled. HLA class I and II alleles were genotyped using polymerase chain reaction-sequence specific oligonucleotides (PCR-SSOs). CYP2C9, CYP2C19, and CYP3A4 genotypes were determined by the TaqMan real-time PCR assay. We performed computational analyses of dapsone and DDS-NHOH interacting with HLA-B*13:01 and HLA-B*13:02 alleles by the molecular docking approach. Among all the HLA alleles, only HLA-B*13:01 allele was found to be significantly associated with dapsone-induced SCARs (OR = 39.00, 95% CI = 7.67-198.21, p = 5.3447 × 10-7), SJS-TEN (OR = 36.00, 95% CI = 3.19-405.89, p = 2.1657 × 10-3), and DRESS (OR = 40.50, 95% CI = 6.38-257.03, p = 1.0784 × 10-5) as compared to dapsone-tolerant controls. Also, HLA-B*13:01 allele was strongly associated with dapsone-induced SCARs in Asians (OR = 36.00, 95% CI = 8.67-149.52, p = 2.8068 × 10-7) and Taiwanese (OR = 31.50, 95% CI = 4.80-206.56, p = 2.5519 × 10-3). Furthermore, dapsone and DDS-NHOH fit within the extra-deep sub pocket of the antigen-binding site of the HLA-B*13:01 allele and change the antigen-recognition site. However, there was no significant association between genetic polymorphism of cytochrome P450 (CYP2C9, CYP2C19, and CYP3A4) and dapsone-induced SCARs (SJS-TEN and DRESS). The results of this study support the specific genotyping of the HLA-B*13:01 allele to avoid dapsone-induced SCARs including SJS-TEN and DRESS before initiating dapsone therapy in the Asian population."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.org/dc/terms/identifier"doi:10.3389/fimmu.2021.661135"xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Wang C.W."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Chung W.H."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Pirmohamed M."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Rungrotmongkol T."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Sukasem C."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Tempark T."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Tassaneeyakul W."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Klaewsongkram J."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Jantararoungtong T."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Khunarkornsiri U."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Konyoung P."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Koomdee N."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Mahakkanukrauh A."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Nakkam N."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Rerkpattanapipat T."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Saksit N."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Satapornpong P."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Pratoomwun J."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Rerknimitr P."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Amornpinyo W."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Ariyachaipanich M."xsd:string
http://purl.uniprot.org/citations/34017337http://purl.uniprot.org/core/author"Jinda P."xsd:string
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