| http://purl.uniprot.org/citations/34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34021541 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the role of microRNA (miR)-485 and its downstream signaling molecules on mediating epilepsy in cellular and rat models. We established a cellular epilepsy model by exposing hippocampal neurons to magnesium and a rat model by treating ICR mice with lithium chloride (127 mg/kg) and pilocarpine (30 mg/kg). We confirmed that miR-485 could bind and inhibit histone deacetylase 5 (HDAC5) and then measured expression of miR-485 and in mice and cells. Cells were transfected with overexpression or knockdown of miR-485, HDAC5, hypoxia-inducible factor-1alpha (HIF1α), or 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 enzyme (PFKFB3) to verify their roles in apoptosis, oxidative stress, and inflammation in epileptic hippocampal neurons. Binding relationship between miR-485, HDAC5, HIF1α, and PFKFB3 was verified. Oxidative stress and inflammation marker levels in epilepsy model mice were assessed. miR-485 was downregulated and HDAC5 was upregulated in cell and animal model of epilepsy. Seizure, neuronal apoptosis, oxidative stress (increased SOD and GSH-Px expression and decreased MDA and 8-OHdG expression) and inflammation (reduced IL-1β, TNF-α, and IL-6 expression) were reduced by miR-485 in epileptic cells. HIF1α and PFKFB3 expression was reduced by HDAC5 knockdown in cells, which was recapitulated in vivo. Thus, miR-485 alleviates neuronal damage and epilepsy by inhibiting HDAC5, HIF1α, and PFKFB3."xsd:string |
| http://purl.uniprot.org/citations/34021541 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.203058"xsd:string |
| http://purl.uniprot.org/citations/34021541 | http://purl.uniprot.org/core/author | "Hu Q."xsd:string |
| http://purl.uniprot.org/citations/34021541 | http://purl.uniprot.org/core/author | "Pan W."xsd:string |
| http://purl.uniprot.org/citations/34021541 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/34021541 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/34021541 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34021541 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/34021541 | http://purl.uniprot.org/core/pages | "14416-14432"xsd:string |
| http://purl.uniprot.org/citations/34021541 | http://purl.uniprot.org/core/title | "miR-485 inhibits histone deacetylase HDAC5, HIF1alpha and PFKFB3 expression to alleviate epilepsy in cellular and rodent models."xsd:string |
| http://purl.uniprot.org/citations/34021541 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/34021541 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34021541 |
| http://purl.uniprot.org/citations/34021541 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34021541 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY64-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E9-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |
| http://purl.uniprot.org/uniprot/#_A2AUP1-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |
| http://purl.uniprot.org/uniprot/#_A2AUP5-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |
| http://purl.uniprot.org/uniprot/#_A7UAK4-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |
| http://purl.uniprot.org/uniprot/#_A7UAK5-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |
| http://purl.uniprot.org/uniprot/#_A7UAK8-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |
| http://purl.uniprot.org/uniprot/#_B7ZDF5-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |
| http://purl.uniprot.org/uniprot/#_B7ZDF7-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |
| http://purl.uniprot.org/uniprot/#_Q3U2E0-mappedCitation-34021541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34021541 |