| http://purl.uniprot.org/citations/34029573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34029573 | http://www.w3.org/2000/01/rdf-schema#comment | "Functional studies to delineate the molecular mechanisms of causal genetic variants are the main focus in the post-GWAS era. Previous GWASs have identified >50 susceptibility loci associated with psoriasis. Functional understanding of the biology underlying the disease risk of most of these associated loci is unclear. In this study, we identified a regulatory SNP at the putative enhancer of the LCE3A gene within the epidermal differentiation complex that showed epistatic interaction with HLA-Cw6. The variant allele disrupted signal transducer and activator of transcription 3 binding to the region, thereby regulating the expression of the downstream LCE3A gene. Electrophoretic mobility shift and pulldown assay confirmed the preferential binding of signal transducer and activator of transcription 3 to the DNA with a wild-type allele compared with the DNA with a variant allele. The reporter assay further validated the IL-6‒stimulated phosphorylated signal transducer and activator of transcription 3‒mediated LCE3A activation in the presence of the wild-type allele. Interestingly, the presence of the HLA-Cw6 allele leads to IL-6‒mediated phosphorylation of signal transducer and activator of transcription 3, followed by its nuclear localization in the epidermal keratinocytes of psoriatic skin, suggesting indirect interaction of the HLA-Cw6 allele and a regulatory SNP upstream of the LCE3A gene. This study reflects an interesting approach to dissecting the molecular mechanism underlying the genetic interaction observed between HLA-Cw6 and LCE3A in psoriasis pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jid.2021.04.020"xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/author | "Mazumder S."xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/author | "Das S."xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/author | "Senapati S."xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/author | "Chatterjee G."xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/author | "Chandra A."xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/author | "Chatterjee R."xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/pages | "2630-2638.e7"xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/title | "Functional Mapping of Genetic Interactions between HLA-Cw6 and LCE3A in Psoriasis."xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/34029573 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34029573 |
| http://purl.uniprot.org/citations/34029573 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34029573 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-34029573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34029573 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-34029573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34029573 |
| http://purl.uniprot.org/uniprot/#_A0A089N0V0-mappedCitation-34029573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34029573 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C850-mappedCitation-34029573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34029573 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C8P1-mappedCitation-34029573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34029573 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C8P4-mappedCitation-34029573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34029573 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C8P8-mappedCitation-34029573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34029573 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C8Q2-mappedCitation-34029573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34029573 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC64-mappedCitation-34029573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34029573 |