| http://purl.uniprot.org/citations/34031358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34031358 | http://www.w3.org/2000/01/rdf-schema#comment | "Human intestinal peptide transporter PEPT1 is commonly repressed in human colorectal cancer (CRC), yet its relationship with sensitivity to the common CRC treatment ubenimex has not previously been elucidated. In this study, we confirmed PEPT1 suppression in CRC using real-time quantitative polymerase chain reaction and western blotting and then investigated the underlying epigenetic pathways involved using bisulfite sequencing, chromatin immunoprecipitation, siRNA knockdown, and reporter gene assays. We found that PEPT1 transcriptional repression was due to both DNMT1-mediated DNA methylation of the proximal promoter region and HDAC1-mediated histone deacetylation, which blocked P300-mediated H3K18/27Ac at the PEPT1 distal promoter. Finally, the effects of the epigenetic activation of PEPT1 on the CRC response to ubenimex were evaluated using sequential combination therapy of decitabine and ubenimex both in vitro and in xenografts. In conclusion, epigenetic silencing of PEPT1 due to increased DNMT1 and HDAC1 expression plays a vital role in the poor response of CRC to ubenimex."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-021-03814-5"xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/author | "Qiu L."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/author | "Zeng S."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/author | "Zheng X."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/author | "Hua Y."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/pages | "532"xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/title | "Epigenetic regulation of intestinal peptide transporter PEPT1 as a potential strategy for colorectal cancer sensitization."xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34031358 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34031358 |
| http://purl.uniprot.org/citations/34031358 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34031358 |
| http://purl.uniprot.org/uniprot/#_B2CQT6-mappedCitation-34031358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34031358 |
| http://purl.uniprot.org/uniprot/#_P46059-mappedCitation-34031358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34031358 |
| http://purl.uniprot.org/uniprot/#_Q4VAL9-mappedCitation-34031358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34031358 |
| http://purl.uniprot.org/uniprot/#_O14496-mappedCitation-34031358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34031358 |
| http://purl.uniprot.org/uniprot/#_O43641-mappedCitation-34031358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34031358 |
| http://purl.uniprot.org/uniprot/#_Q6GV26-mappedCitation-34031358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34031358 |