| http://purl.uniprot.org/citations/34032851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34032851 | http://www.w3.org/2000/01/rdf-schema#comment | "Ligand binding triggers clathrin-mediated and, at high ligand concentrations, clathrin-independent endocytosis of EGFR. Clathrin-mediated endocytosis (CME) of EGFR is also induced by stimuli activating p38 MAPK. Mechanisms of both ligand- and p38-induced endocytosis are not fully understood, and how these pathways intermingle when concurrently activated remains unknown. Here we dissect the mechanisms of p38-induced endocytosis using a pH-sensitive model of endogenous EGFR, which is extracellularly tagged with a fluorogen-activating protein, and propose a unifying model of the crosstalk between multiple EGFR endocytosis pathways. We found that a new locus of p38-dependent phosphorylation in EGFR is essential for the receptor dileucine motif interaction with the σ2 subunit of clathrin adaptor AP2 and concomitant receptor internalization. p38-dependent endocytosis of EGFR induced by cytokines was additive to CME induced by picomolar EGF concentrations but constrained to internalizing ligand-free EGFRs due to Grb2 recruitment by ligand-activated EGFRs. Nanomolar EGF concentrations rerouted EGFR from CME to clathrin-independent endocytosis, primarily by diminishing p38-dependent endocytosis."xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.202102005"xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/author | "Sakurai H."xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/author | "Gygi S."xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/author | "Watkins S.C."xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/author | "Sorkin A."xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/author | "Paulo J.A."xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/author | "Perez Verdaguer M."xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/pages | "e202102005"xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/title | "Mechanism of p38 MAPK-induced EGFR endocytosis and its crosstalk with ligand-induced pathways."xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://purl.uniprot.org/core/volume | "220"xsd:string |
| http://purl.uniprot.org/citations/34032851 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34032851 |
| http://purl.uniprot.org/citations/34032851 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34032851 |
| http://purl.uniprot.org/uniprot/#_A0A068JD88-mappedCitation-34032851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34032851 |
| http://purl.uniprot.org/uniprot/#_A0A068JCC9-mappedCitation-34032851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34032851 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F8-mappedCitation-34032851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34032851 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F4-mappedCitation-34032851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34032851 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9F6-mappedCitation-34032851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34032851 |
| http://purl.uniprot.org/uniprot/#_A0A1Y0B9G5-mappedCitation-34032851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34032851 |
| http://purl.uniprot.org/uniprot/#_A0A384ME16-mappedCitation-34032851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34032851 |
| http://purl.uniprot.org/uniprot/#_A8K2T7-mappedCitation-34032851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34032851 |