| http://purl.uniprot.org/citations/34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34033822 | http://www.w3.org/2000/01/rdf-schema#comment | "External genital organs are among the most recognizable sexually dimorphic characters. The penis and clitoris develop from the embryonic genital tubercle, an outgrowth at the anterior margin of the cloaca that undergoes an extensive period of development in male and female embryos prior to the onset of sexual differentiation. In mice, differentiation into the penis and clitoris begins around embryonic day (E)15.5. Current knowledge of cell types that comprise the genital tubercle is limited to a few studies that have fate mapped derivatives of endoderm, mesoderm, and ectoderm. Here we use single cell transcriptomics to characterize the cell populations in the genital tubercles of male and female mouse embryos at E14.5, approximately 24 h before the onset of sexual differentiation, and we present the first comprehensive atlas of single-cell gene expression during external genital development. Clustering analyses and annotation using marker genes shows 19 distinct cell populations in E14.5 genital tubercles. Mapping of cell clusters to anatomical locations using in situ gene expression patterns revealed granularity of cellular specializations and positional identities. Although E14.5 precedes sexually dimorphic morphogenesis of the genital tubercle, comparative analysis of males and females identified sexual dimorphisms at the single cell level, including male-specific cell clusters with transcriptional signatures of smooth muscle and bone progenitors, both of which are known to be sexually dimorphic in adult genitalia, as well as immune cells. These results provide a new resource for classification of external genital cell types based on gene expression profiles and reveal sex-specific cellular specializations in the early genital tubercle."xsd:string |
| http://purl.uniprot.org/citations/34033822 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2021.05.014"xsd:string |
| http://purl.uniprot.org/citations/34033822 | http://purl.uniprot.org/core/author | "Cohn M.J."xsd:string |
| http://purl.uniprot.org/citations/34033822 | http://purl.uniprot.org/core/author | "Armfield B.A."xsd:string |
| http://purl.uniprot.org/citations/34033822 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34033822 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/34033822 | http://purl.uniprot.org/core/pages | "145-154"xsd:string |
| http://purl.uniprot.org/citations/34033822 | http://purl.uniprot.org/core/title | "Single cell transcriptomic analysis of external genitalia reveals complex and sexually dimorphic cell populations in the early genital tubercle."xsd:string |
| http://purl.uniprot.org/citations/34033822 | http://purl.uniprot.org/core/volume | "477"xsd:string |
| http://purl.uniprot.org/citations/34033822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34033822 |
| http://purl.uniprot.org/citations/34033822 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34033822 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SR88-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_A5D6P6-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_A0A2C9NTD7-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_G3UZS0-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_Q3U0R0-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_P08551-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_Q2TJ95-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_Q3UQH0-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_P70314-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_Q05DD2-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_Q61080-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_Q9D030-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |
| http://purl.uniprot.org/uniprot/#_Q9D0L6-mappedCitation-34033822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34033822 |