| http://purl.uniprot.org/citations/34035258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34035258 | http://www.w3.org/2000/01/rdf-schema#comment | "INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to PI3K regulation is unclear. We report PIK3CA-mutant ER+ breast cancers exhibit increased INPP4B mRNA and protein expression and INPP4B increased the proliferation and tumor growth of PIK3CA-mutant ER+ breast cancer cells, despite suppression of AKT signaling. We used integrated proteomics, transcriptomics and imaging to demonstrate INPP4B localized to late endosomes via interaction with Rab7, which increased endosomal PI3Kα-dependent PI(3,4)P2 to PI(3)P conversion, late endosome/lysosome number and cargo trafficking, resulting in enhanced GSK3β lysosomal degradation and activation of Wnt/β-catenin signaling. Mechanistically, Wnt inhibition or depletion of the PI(3)P-effector, Hrs, reduced INPP4B-mediated cell proliferation and tumor growth. Therefore, INPP4B facilitates PI3Kα crosstalk with Wnt signaling in ER+ breast cancer via PI(3,4)P2 to PI(3)P conversion on late endosomes, suggesting these tumors may be targeted with combined PI3K and Wnt/β-catenin therapies."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-23241-6"xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Daly R.J."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Schittenhelm R.B."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Abud H.E."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Kerr G."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Papa A."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Mitchell C.A."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "McLean C.A."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Gurung R."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Ooms L.M."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Ramm G."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Ellisdon A.M."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Sriratana A."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Nguyen E.V."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Fedele C.G."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Loi S."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Caramia F."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Rodgers S.J."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Eramo M.J."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Hamila S.A."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Oorschot V.M.J."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/author | "Rynkiewicz N."xsd:string |
| http://purl.uniprot.org/citations/34035258 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |