| http://purl.uniprot.org/citations/34035267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34035267 | http://www.w3.org/2000/01/rdf-schema#comment | "Meis1 and Meis2 are homeodomain transcription factors that regulate organogenesis through cooperation with Hox proteins. Elimination of Meis genes after limb induction has shown their role in limb proximo-distal patterning; however, limb development in the complete absence of Meis function has not been studied. Here, we report that Meis1/2 inactivation in the lateral plate mesoderm of mouse embryos leads to limb agenesis. Meis and Tbx factors converge in this function, extensively co-binding with Tbx to genomic sites and co-regulating enhancers of Fgf10, a critical factor in limb initiation. Limbs with three deleted Meis alleles show proximal-specific skeletal hypoplasia and agenesis of posterior skeletal elements. This failure in posterior specification results from an early role of Meis factors in establishing the limb antero-posterior prepattern required for Shh activation. Our results demonstrate roles for Meis transcription factors in early limb development and identify their involvement in previously undescribed interaction networks that regulate organogenesis."xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-23373-9"xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/author | "Drouin J."xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/author | "Torres M."xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/author | "Delgado I."xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/author | "Giovinazzo G."xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/author | "Gauthier Y."xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/author | "Balsalobre A."xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/author | "Temino S."xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/pages | "3086"xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/title | "Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors."xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34035267 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34035267 |
| http://purl.uniprot.org/citations/34035267 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34035267 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQB8-mappedCitation-34035267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34035267 |
| http://purl.uniprot.org/uniprot/#_A0A0A7EPH8-mappedCitation-34035267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34035267 |
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| http://purl.uniprot.org/uniprot/#_Q3UJ00-mappedCitation-34035267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34035267 |
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| http://purl.uniprot.org/uniprot/#_P97367-mappedCitation-34035267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34035267 |