| http://purl.uniprot.org/citations/34048700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34048700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34048700 | http://www.w3.org/2000/01/rdf-schema#comment | "Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity, which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein-coupled receptors (GPCRs). Here, we uncover an alternate paradigm of GPCR-mediated adipose thermogenesis through the constitutively active receptor, GPR3. We show that the N terminus of GPR3 confers intrinsic signaling activity, resulting in continuous Gs-coupling and cAMP production without an exogenous ligand. Thus, transcriptional induction of Gpr3 represents the regulatory parallel to ligand-binding of conventional GPCRs. Consequently, increasing Gpr3 expression in thermogenic adipocytes is alone sufficient to drive energy expenditure and counteract metabolic disease in mice. Gpr3 transcription is cold-stimulated by a lipolytic signal, and dietary fat potentiates GPR3-dependent thermogenesis to amplify the response to caloric excess. Moreover, we find GPR3 to be an essential, adrenergic-independent regulator of human brown adipocytes. Taken together, our findings reveal a noncanonical mechanism of GPCR control and thermogenic activation through the lipolysis-induced expression of constitutively active GPR3."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2021.04.037"xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2021.04.037"xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Dong H."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Dong H."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Hansen T."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Hansen T."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "McGonigle S."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "McGonigle S."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Pfeifer A."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Pfeifer A."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Schreiber R."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Schreiber R."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Treebak J.T."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Treebak J.T."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Pedersen O."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Pedersen O."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Granneman J.G."xsd:string |
| http://purl.uniprot.org/citations/34048700 | http://purl.uniprot.org/core/author | "Granneman J.G."xsd:string |