| http://purl.uniprot.org/citations/34048907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34048907 | http://www.w3.org/2000/01/rdf-schema#comment | "The retina is a highly active metabolic organ that displays a particular vulnerability to genetic and environmental factors causing stress and homeostatic imbalance. Mitochondria constitute a bioenergetic hub that coordinates stress response and cellular homeostasis, therefore structural and functional regulation of the mitochondrial dynamic network is essential for the mammalian retina. CERKL (ceramide kinase like) is a retinal degeneration gene whose mutations cause Retinitis Pigmentosa in humans, a visual disorder characterized by photoreceptors neurodegeneration and progressive vision loss. CERKL produces multiple isoforms with a dynamic subcellular localization. Here we show that a pool of CERKL isoforms localizes at mitochondria in mouse retinal ganglion cells. The depletion of CERKL levels in CerklKD/KO(knockdown/knockout) mouse retinas cause increase of autophagy, mitochondrial fragmentation, alteration of mitochondrial distribution, and dysfunction of mitochondrial-dependent bioenergetics and metabolism. Our results support CERKL as a regulator of autophagy and mitochondrial biology in the mammalian retina."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.nbd.2021.105405"xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/author | "Villarroya F."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/author | "Marfany G."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/author | "Artuch R."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/author | "Oliva C."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/author | "Garcia-Fernandez J."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/author | "Mirra S."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/author | "Gavalda-Navarro A."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/author | "Herrera-Ubeda C."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/author | "Garcia-Arroyo R."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/author | "B Domenech E."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/name | "Neurobiol Dis"xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/pages | "105405"xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/title | "CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina."xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://purl.uniprot.org/core/volume | "156"xsd:string |
| http://purl.uniprot.org/citations/34048907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34048907 |
| http://purl.uniprot.org/citations/34048907 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34048907 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGG3-mappedCitation-34048907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34048907 |
| http://purl.uniprot.org/uniprot/#_E9Q9J5-mappedCitation-34048907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34048907 |
| http://purl.uniprot.org/uniprot/#_E9QAM0-mappedCitation-34048907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34048907 |
| http://purl.uniprot.org/uniprot/#_G0XYF0-mappedCitation-34048907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34048907 |
| http://purl.uniprot.org/uniprot/#_G0XYF1-mappedCitation-34048907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34048907 |