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http://purl.uniprot.org/citations/34059446http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34059446http://www.w3.org/2000/01/rdf-schema#comment"

Objective

We have previously revealed the clinical factors and genetic polymorphisms associated with gastrointestinal mucosal injury and bleeding, induced by low-dose aspirin (LDA). After performing genome-wide analysis of single nucleotide polymorphisms (SNPs) using the Drug Metabolizing Enzymes and Transporters (DMET) system among drug metabolism and transporter genes, certain SNPs were found to increase the risk for LDA-induced small bowel bleeding. The aim of this study was to identify the SNPs involved in LDA-induced small bowel bleeding.

Subjects and methods

Subjects were patients taking LDA, with small bowel bleeding diagnosed using capsule endoscopy. We investigated the clinical characteristics and the previously identified SNPs, that were examined by the DNA direct sequence method.

Results

56 patients with bleeding and 410 controls taking LDA were enrolled. The risk factors associated with small bowel bleeding included smoking, cerebrovascular diseases, chronic renal failure, non-steroidal anti-inflammatory drug (NSAID) or anticoagulants combination, and two SNPs (CYP4F11 20043G>A (D446N) rs1060463, GSTP1 313A>G rs1695). After propensity score matching, GSTP1 rs1695 was significantly associated with small bowel bleeding.

Conclusion

The GSTP1 SNP may be a predictive marker for small bowel bleeding among patients taking LDA."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.org/dc/terms/identifier"doi:10.1016/j.dld.2021.04.038"xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/author"Matsumoto H."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/author"Osawa M."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/author"Handa Y."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/author"Fukushima S."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/author"Sakakibara T."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/author"Shiotani A."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/author"Handa O."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/author"Umegaki E."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/author"Murao T."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/author"Yo S."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/name"Dig Liver Dis"xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/pages"841-845"xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/title"A novel gene associated with small bowel bleeding in patients taking low-dose aspirin."xsd:string
http://purl.uniprot.org/citations/34059446http://purl.uniprot.org/core/volume"53"xsd:string
http://purl.uniprot.org/citations/34059446http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34059446
http://purl.uniprot.org/citations/34059446http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/34059446
http://purl.uniprot.org/uniprot/#_A0A0M5MRY8-mappedCitation-34059446http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34059446
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http://purl.uniprot.org/uniprot/#_A0A2P1FDF0-mappedCitation-34059446http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34059446
http://purl.uniprot.org/uniprot/#_A0A3B6XSH2-mappedCitation-34059446http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34059446
http://purl.uniprot.org/uniprot/#_B2C310-mappedCitation-34059446http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34059446
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