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| http://purl.uniprot.org/citations/34069970 | http://www.w3.org/2000/01/rdf-schema#comment | "Prostate cancer (PCa) is the second most leading cause of death in males. Our previous studies have demonstrated that δ-catenin plays an important role in prostate cancer progression. However, the molecular mechanism underlying the regulation of δ-catenin has not been fully explored yet. In the present study, we found that δ-catenin could induce phosphorylation of p21Waf and stabilize p21 in the cytoplasm, thus blocking its nuclear accumulation for the first time. We also found that δ-catenin could regulate the interaction between AKT and p21, leading to phosphorylation of p21 at Thr-145 residue. Finally, EGF was found to be a key factor upstream of AKT/δ-catenin/p21 for promoting proliferation and metastasis in prostate cancer. Our findings provide new insights into molecular controls of EGF and the development of potential therapeutics targeting δ-catenin to control prostate cancer progression."xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms22105306"xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/author | "Zhou R."xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/author | "Lee H.J."xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/author | "Cho Y.C."xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/pages | "5306"xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/title | "delta-Catenin Participates in EGF/AKT/p21pisup>Wafpi/sup> Signaling and Induces Prostate Cancer Cell Proliferation and Invasion."xsd:string |
| http://purl.uniprot.org/citations/34069970 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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