| http://purl.uniprot.org/citations/34080635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34080635 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite the recognized significance of reversible protein lipidation (S-acylation) for T cell receptor signal transduction, the enzymatic control of this post-translational modification in T cells remains poorly understood. Here, we demonstrate that DHHC21 (also known as ZDHHC21), a member of the DHHC family of mammalian protein acyltransferases, mediates T cell receptor-induced S-acylation of proximal T cell signaling proteins. Using Zdhhc21dep mice, which express a functionally deficient version of DHHC21, we show that DHHC21 is a Ca2+/calmodulin-dependent enzyme critical for activation of naïve CD4+ T cells in response to T cell receptor stimulation. We find that disruption of the Ca2+/calmodulin-binding domain of DHHC21 does not affect thymic T cell development but prevents differentiation of peripheral CD4+ T cells into Th1, Th2 and Th17 effector T helper lineages. Our findings identify DHHC21 as an essential component of the T cell receptor signaling machinery and define a new role for protein acyltransferases in regulation of T cell-mediated immunity."xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.258186"xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/author | "Fan Y."xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/author | "Tewari R."xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/author | "Boehning D."xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/author | "Ko J."xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/author | "Mills T."xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/author | "Akimzhanov A.M."xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/author | "West S.J."xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/author | "Bieerkehazhi S."xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/pages | "jcs258186"xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/title | "Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells."xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/34080635 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34080635 |
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