| http://purl.uniprot.org/citations/34095875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34095875 | http://www.w3.org/2000/01/rdf-schema#comment | "Humoral immune responses are dysregulated with aging, but the cellular and molecular pathways involved remain incompletely understood. In particular, little is known about the effects of aging on T follicular helper (Tfh) CD4 cells, the key cells that provide help to B cells for effective humoral immunity. We performed transcriptional profiling and cellular analysis on circulating Tfh before and after influenza vaccination in young and elderly adults. First, whole-blood transcriptional profiling shows that ICOS+CD38+ cTfh following vaccination preferentially enriches in gene sets associated with youth versus aging compared to other circulating T cell types. Second, vaccine-induced ICOS+CD38+ cTfh from the elderly had increased the expression of genes associated with inflammation, including tumor necrosis factor-nuclear factor κB (TNF-NF-κB) pathway activation. Finally, vaccine-induced ICOS+CD38+ cTfh display strong enrichment for signatures of underlying age-associated biological changes. These data highlight the ability to use vaccine-induced cTfh as cellular "biosensors" of underlying inflammatory and/or overall immune health."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.xcrm.2021.100262"xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Silva L.V."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Kannan S."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Wherry E.J."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Canaday D.H."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Doyle S.A."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Kossenkov A.V."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Bengsch B."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Manne S."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Alanio C."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Herati R.S."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Vella L.A."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Schmader K.E."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Muselman A."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Kurupati R.K."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/author | "Ertl H.C.J."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/name | "Cell Rep Med"xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/pages | "100262"xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/title | "Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways."xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/34095875 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34095875 |
| http://purl.uniprot.org/citations/34095875 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34095875 |