| http://purl.uniprot.org/citations/34099715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34099715 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms regulating myelin repair in the adult central nervous system (CNS) are unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven-Translocation (TET) enzyme TET1, as necessary for myelin repair in young adults and defective in old mice. Constitutive and inducible oligodendrocyte lineage-specific ablation of Tet1 (but not of Tet2), recapitulate this age-related decline in repair of demyelinated lesions. DNA hydroxymethylation and transcriptomic analyses identify TET1-target in adult oligodendrocytes, as genes regulating neuro-glial communication, including the solute carrier (Slc) gene family. Among them, we show that the expression levels of the Na+/K+/Cl- transporter, SLC12A2, are higher in Tet1 overexpressing cells and lower in old or Tet1 knockout. Both aged mice and Tet1 mutants also present inefficient myelin repair and axo-myelinic swellings. Zebrafish mutants for slc12a2b also display swellings of CNS myelinated axons. Our findings suggest that TET1 is required for adult myelin repair and regulation of the axon-myelin interface."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-23735-3"xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Huang D."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Jiang Y.H."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Marechal D."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Lyons D.A."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Mobius W."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Sadowski B."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Kegel L."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Casaccia P."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Moyon S."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Frawley R."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Marshall-Phelps K.L.H."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/author | "Bostrand S.M.K."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/pages | "3359"xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/title | "TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice."xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34099715 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34099715 |
| http://purl.uniprot.org/citations/34099715 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34099715 |
| http://purl.uniprot.org/uniprot/A0A8M1RPE8#attribution-E395830321D70FF3C91453CA3F980616 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/34099715 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG87-mappedCitation-34099715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34099715 |
| http://purl.uniprot.org/uniprot/#_D0VLQ5-mappedCitation-34099715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34099715 |