| http://purl.uniprot.org/citations/34103493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34103493 | http://www.w3.org/2000/01/rdf-schema#comment | "Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profile, characterized by oncogenic BRAF mutations and aberrations in mismatch repair and TGFβ signalling. Here, we describe a mouse model of right-sided colon cancer driven by oncogenic BRAF and loss of epithelial TGFβ-receptor signalling. The proximal colonic tumours that develop in this model exhibit a foetal-like progenitor phenotype (Ly6a/Sca1+) and, importantly, lack expression of Lgr5 and its associated intestinal stem cell signature. These features are recapitulated in human BRAF-mutant, right-sided CRCs and represent fundamental differences between left- and right-sided disease. Microbial-driven inflammation supports the initiation and progression of these tumours with foetal-like characteristics, consistent with their predilection for the microbe-rich right colon and their antibiotic sensitivity. While MAPK-pathway activating mutations drive this foetal-like signature via ERK-dependent activation of the transcriptional coactivator YAP, the same foetal-like transcriptional programs are also initiated by inflammation in a MAPK-independent manner. Importantly, in both contexts, epithelial TGFβ-receptor signalling is instrumental in suppressing the tumorigenic potential of these foetal-like progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-23717-5"xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Campbell A.D."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Frame M.C."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Shaw R."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Fey S."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Holmes C."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Campbell P."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Kaplan R."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Brown L."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Clark W."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Tomlinson I."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Hughes M."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Medema J.P."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Quirke P."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Thompson B.J."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Leedham S.J."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Ridgway R.A."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Tejpar S."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Sansom O.J."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Inman G.J."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Leedham S."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Salto-Tellez M."xsd:string |
| http://purl.uniprot.org/citations/34103493 | http://purl.uniprot.org/core/author | "Sphyris N."xsd:string |