| http://purl.uniprot.org/citations/34112787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34112787 | http://www.w3.org/2000/01/rdf-schema#comment | "Decreased pleasure-seeking (anhedonia) forms a core symptom of depression. Stressful experiences precipitate depression and disrupt reward-seeking, but it remains unclear how stress causes anhedonia. We recorded simultaneous neural activity across limbic brain areas as mice underwent stress and discovered a stress-induced 4 Hz oscillation in the nucleus accumbens (NAc) that predicts the degree of subsequent blunted reward-seeking. Surprisingly, while previous studies on blunted reward-seeking focused on dopamine (DA) transmission from the ventral tegmental area (VTA) to the NAc, we found that VTA GABA, but not DA, neurons mediate stress-induced blunted reward-seeking. Inhibiting VTA GABA neurons disrupts stress-induced NAc oscillations and rescues reward-seeking. By contrast, mimicking this signature of stress by stimulating NAc-projecting VTA GABA neurons at 4 Hz reproduces both oscillations and blunted reward-seeking. Finally, we find that stress disrupts VTA GABA, but not DA, neural encoding of reward anticipation. Thus, stress elicits VTA-NAc GABAergic activity that induces VTA GABA mediated blunted reward-seeking."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-23906-2"xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Park A.J."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Gordon J.A."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Abbas A.I."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Lowes D.C."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Harris A.Z."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Kretsge L.N."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Bretton Z.H."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Chamberlin L.A."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Enikolopov A.G."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Firdous A."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Holt E.S."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/author | "Yusufova L."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/pages | "3539"xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/title | "Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice."xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34112787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34112787 |
| http://purl.uniprot.org/citations/34112787 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34112787 |
| http://purl.uniprot.org/uniprot/#_O35633-mappedCitation-34112787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34112787 |
| http://purl.uniprot.org/uniprot/#_Q49S98-mappedCitation-34112787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34112787 |
| http://purl.uniprot.org/uniprot/#_Q3UVW5-mappedCitation-34112787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34112787 |