| http://purl.uniprot.org/citations/34116057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34116057 | http://www.w3.org/2000/01/rdf-schema#comment | "The Elongin complex was originally identified as an RNA polymerase II (RNAPII) elongation factor and subsequently as the substrate recognition component of a Cullin-RING E3 ubiquitin ligase. More recent evidence indicates that the Elongin ubiquitin ligase assembles with the Cockayne syndrome B helicase (CSB) in response to DNA damage and can target stalled polymerases for ubiquitylation and removal from the genome. In this report, we present evidence that the CSB-Elongin ubiquitin ligase pathway has roles beyond the DNA damage response in the activation of RNAPII-mediated transcription. We observed that assembly of the CSB-Elongin ubiquitin ligase is induced not just by DNA damage, but also by a variety of signals that activate RNAPII-mediated transcription, including endoplasmic reticulum (ER) stress, amino acid starvation, retinoic acid, glucocorticoids, and doxycycline treatment of cells carrying several copies of a doxycycline-inducible reporter. Using glucocorticoid receptor (GR)-regulated genes as a model, we showed that glucocorticoid-induced transcription is accompanied by rapid recruitment of CSB and the Elongin ubiquitin ligase to target genes in a step that depends upon the presence of transcribing RNAPII on those genes. Consistent with the idea that the CSB-Elongin pathway plays a direct role in GR-regulated transcription, mouse cells lacking the Elongin subunit Elongin A exhibit delays in both RNAPII accumulation on and dismissal from target genes following glucocorticoid addition and withdrawal, respectively. Taken together, our findings bring to light a new role for the CSB-Elongin pathway in RNAPII-mediated transcription."xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jbc.2021.100862"xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/author | "Conaway J.W."xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/author | "Conaway R.C."xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/author | "Slaughter B.D."xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/author | "Unruh J.R."xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/author | "Weems J.C."xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/author | "Delventhal K.M."xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/author | "Miller B.D."xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/author | "Weaver K.J."xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/pages | "100862"xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/title | "A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription."xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/34116057 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34116057 |
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