| http://purl.uniprot.org/citations/34119828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34119828 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetes mellitus (DM) influence induces poor osseointegration. The osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is a critical factor in successful dental implants. Certain microRNAs play important roles during bone development, and others are deregulated in diabetes. This study investigated the roles of miR-129-5p in the osteoblast differentiation regulation. Exosomes containing miR-129-5p inhibited the osteoblast differentiation and was found in the blood of DM rats. The BMSCs isolated from the jaw of rats were used to detect the miR-129-5p expression. Frizzled (FZD) proteins function as receptors for WNT ligands. The FZD4 was the target of miR-129-5p in dual luciferase assay and Western blot. The miR-129-5p inhibited osteoblast differentiation and decreased the osteoblast markers. The exosomes isolated from the blood of DM rats showed more miR-129-5p level. Results suggested that the exosomes containing miR-129-5p maybe regulators of BMSCs in jaw. The collected exosomes containing miR-129-5p showed the inhibition effect in osteoblast differentiation and decreased the expression osteoblastic markers by targeting FZD4/β-catenin signaling pathway. Therefore, the exosomes containing miR-129-5p in DM rats inhibits osteoblast differentiation by targeting FZD4/β-catenin pathway."xsd:string |
| http://purl.uniprot.org/citations/34119828 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2021.05.072"xsd:string |
| http://purl.uniprot.org/citations/34119828 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/34119828 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/34119828 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/34119828 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/34119828 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34119828 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/34119828 | http://purl.uniprot.org/core/pages | "87-93"xsd:string |
| http://purl.uniprot.org/citations/34119828 | http://purl.uniprot.org/core/title | "miR-129-5p in exosomes inhibits diabetes-associated osteogenesis in the jaw via targeting FZD4."xsd:string |
| http://purl.uniprot.org/citations/34119828 | http://purl.uniprot.org/core/volume | "566"xsd:string |
| http://purl.uniprot.org/citations/34119828 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34119828 |
| http://purl.uniprot.org/citations/34119828 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34119828 |
| http://purl.uniprot.org/uniprot/#_A6I5Z8-mappedCitation-34119828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34119828 |
| http://purl.uniprot.org/uniprot/#_Q9QZH0-mappedCitation-34119828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34119828 |
| http://purl.uniprot.org/uniprot/A6I5Z8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34119828 |
| http://purl.uniprot.org/uniprot/Q9QZH0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34119828 |