http://purl.uniprot.org/citations/34127662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/34127662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/34127662 | http://www.w3.org/2000/01/rdf-schema#comment | "Ribosomes are recycled for a new round of translation initiation by dissociation of ribosomal subunits, messenger RNA and transfer RNA from their translational post-termination complex. Here we present cryo-EM structures of the human 55S mitochondrial ribosome (mitoribosome) and the mitoribosomal large 39S subunit in complex with mitoribosome recycling factor (RRFmt) and a recycling-specific homolog of elongation factor G (EF-G2mt). These structures clarify an unusual role of a mitochondria-specific segment of RRFmt, identify the structural distinctions that confer functional specificity to EF-G2mt, and show that the deacylated tRNA remains with the dissociated 39S subunit, suggesting a distinct sequence of events in mitoribosome recycling. Furthermore, biochemical and structural analyses reveal that the molecular mechanism of antibiotic fusidic acid resistance for EF-G2mt is markedly different from that of mitochondrial elongation factor EF-G1mt, suggesting that the two human EF-Gmts have evolved diversely to negate the effect of a bacterial antibiotic."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-23726-4"xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-23726-4"xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Deep A."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Deep A."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Agrawal R.K."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Agrawal R.K."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Koripella R.K."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Koripella R.K."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Agrawal E.K."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Agrawal E.K."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Banavali N.K."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Banavali N.K."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Keshavan P."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/author | "Keshavan P."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/pages | "3607"xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/pages | "3607"xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/title | "Distinct mechanisms of the human mitoribosome recycling and antibiotic resistance."xsd:string |
http://purl.uniprot.org/citations/34127662 | http://purl.uniprot.org/core/title | "Distinct mechanisms of the human mitoribosome recycling and antibiotic resistance."xsd:string |