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http://purl.uniprot.org/citations/34134925http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

The cell surface interleukin 22 (IL-22) receptor complex is mainly expressed in epithelial and tissue cells like pancreatitis cells. Recent studies described that IL-22R was overexpressed in malignant diseases and was associated with a poor overall survival (OS). The role of IL-22RA1 gene expression in muscle invasive bladder cancer (MIBC) has not been investigated, yet.

Objectives

The aim of this study was to analyze the role of IL-22RA1 gene expression in patients with MIBC.

Methods

In a cohort of 114 patients with MIBC who underwent radical cystectomy, IL-22RA1 gene expression was analyzed with qRT-PCR and correlated with clinical parameters. Furthermore, Kaplan-Meier and Cox regression analysis were performed. For validation, an in silico dataset (TCGA 2017, n=407) was reanalyzed.

Results

IL-22RA1 gene expression was independent of clinicopathological parameters like age (P=0.2681), T stage (P=0.2130), nodal status (P=0.3238) and lymph vascular invasion (LVI, P=0.5860) in patients with MIBC. A high expression of IL-22RA1 was associated with a shorter OS (P=0.0040) and disease-specific survival (P=0.0385). Furthermore, a shorter disease-free survival (DFS) was also associated with a high expression of IL-22RA1 (P=0.0102). In the multivariable analysis, IL-22RA1 expression was an independent prognostic predictors regarding OS (P=0.0096, HR=0.48). In the TCGA cohort, IL-22RA1 expression was independent regarding to OS and DFS.

Conclusion

A high IL-22RA1 gene expression was associated with worse outcome. Furthermore, IL-22RA1 represented an independent predictor regarding OS in our cohort and therefore might be used for risk stratification in patients with MIBC."xsd:string
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http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"Porubsky S."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"Neuberger M."xsd:string
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http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"Gaiser T."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"Nuhn P."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"Weidenbusch M."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"Worst T.S."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"von Hardenberg J."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"Thaqi B."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"Kriegmair M."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"Wessels F."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/author"von Rhade S.M."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/name"Urol Oncol"xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/pages"499.e1-499.e8"xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/title"High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer."xsd:string
http://purl.uniprot.org/citations/34134925http://purl.uniprot.org/core/volume"39"xsd:string
http://purl.uniprot.org/citations/34134925http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34134925
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