| http://purl.uniprot.org/citations/34135057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34135057 | http://www.w3.org/2000/01/rdf-schema#comment | "Insufficient autophagic degradation has been implicated in accelerated cellular senescence during chronic obstructive pulmonary disease (COPD) pathogenesis. Aging-linked and cigarette smoke (CS)-induced functional deterioration of lysosomes may be associated with impaired autophagy. Lysosomal membrane permeabilization (LMP) is indicative of damaged lysosomes. Galectin-3 and tripartite motif protein (TRIM) 16 play a cooperative role in recognizing LMP and inducing lysophagy, a lysosome-selective autophagy, to maintain lysosome function. In this study, we sought to examine the role of TRIM16-mediated lysophagy in regulating CS-induced LMP and cellular senescence during COPD pathogenesis by using human bronchial epithelial cells and lung tissues. CS extract (CSE) induced lysosomal damage via LMP, as detected by galectin-3 accumulation. Autophagy was responsible for modulating LMP and lysosome function during CSE exposure. TRIM16 was involved in CSE-induced lysophagy, with impaired lysophagy associated with lysosomal dysfunction and accelerated cellular senescence. Airway epithelial cells in COPD lungs showed an increase in lipofuscin, aggresome and galectin-3 puncta, reflecting accumulation of lysosomal damage with concomitantly reduced TRIM16 expression levels. Human bronchial epithelial cells isolated from COPD patients showed reduced TRIM16 but increased galectin-3, and a negative correlation between TRIM16 and galectin-3 protein levels was demonstrated. Damaged lysosomes with LMP are accumulated in epithelial cells in COPD lungs, which can be at least partly attributed to impaired TRIM16-mediated lysophagy. Increased LMP in lung epithelial cells may be responsible for COPD pathogenesis through the enhancement of cellular senescence."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.2001364"xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Fujita Y."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Fujimoto S."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Hashimoto M."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Hara H."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Ito A."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Mori S."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Yoshida M."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Saito N."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Watanabe J."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Wakui H."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Miyagawa H."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Numata T."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Okuda K."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Minagawa S."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Kawamoto H."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Ohtsuka T."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Ichikawa A."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Kuwano K."xsd:string |
| http://purl.uniprot.org/citations/34135057 | http://purl.uniprot.org/core/author | "Hosaka Y."xsd:string |