| http://purl.uniprot.org/citations/34138470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34138470 | http://www.w3.org/2000/01/rdf-schema#comment | "Intrauterine adhesions (IUA) are characterized by endometrial fibrosis and impose a great challenge for female reproduction. IL-34 is profoundly involved in various fibrotic diseases through regulating the survival, proliferation, and differentiation of monocytes/macrophages. However, it remains unclear how IL-34 regulates monocytes/macrophages in context of IUA. Here, we showed that the expression level of IL-34 and the amount of CX3CR1+ monocytes/macrophages were significantly increased in endometrial tissues of IUA patients. IL-34 promoted the differentiation of monocytes/macrophages, which express CX3CR1 via CSF-1R/P13K/Akt pathway in vitro. Moreover, IL-34-induced CX3CR1+ monocytes/macrophages promoted the differentiation of endometrial stromal cells into myofibroblasts. Of note, IL-34 caused endometrial fibrosis and increased the amount of CX3CR1+ monocytes/macrophages in endometrial tissues in vivo. IL-34 modulated endometrial fibrosis by regulating monocytes/macrophages since the elimination of endometrial monocytes/macrophages significantly suppressed the profibrotic function of IL-34. Finally, blocking of IL-34 in the LPS-IUA model resulted in the improvement of endometrial fibrosis and decreased number of CX3CR1+ monocytes/macrophages. Our studies uncover the novel mechanism of interaction between IL-34-induced CX3CR1+ monocytes/macrophages and endometrial stromal cells in endometrial fibrosis pathogenesis, and highlight IL-34 as a critical target for treating IUA."xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.202149174"xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/author | "Hou Y."xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/author | "Liu D."xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/author | "Jiang Q."xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/author | "Pan Y."xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/pages | "2501-2512"xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/title | "Interleukin-34 accelerates intrauterine adhesions progress related to CX3CR1+ monocytes/macrophages."xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/34138470 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34138470 |
| http://purl.uniprot.org/citations/34138470 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34138470 |
| http://purl.uniprot.org/uniprot/#_Q8BR50-mappedCitation-34138470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34138470 |
| http://purl.uniprot.org/uniprot/#_P49238-mappedCitation-34138470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34138470 |
| http://purl.uniprot.org/uniprot/#_Q543X3-mappedCitation-34138470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34138470 |
| http://purl.uniprot.org/uniprot/#_Q8CBJ0-mappedCitation-34138470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34138470 |
| http://purl.uniprot.org/uniprot/#_Q6ZMJ4-mappedCitation-34138470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34138470 |
| http://purl.uniprot.org/uniprot/#_Q8R1R4-mappedCitation-34138470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34138470 |
| http://purl.uniprot.org/uniprot/#_Q9Z0D9-mappedCitation-34138470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34138470 |
| http://purl.uniprot.org/uniprot/Q8CBJ0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34138470 |