| http://purl.uniprot.org/citations/34142025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34142025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34142025 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondria regulate the immune response after dengue virus (DENV) infection. Microarray analysis of genes identified the upregulation of mitochondrial cytidine/uridine monophosphate kinase 2 (CMPK2) by DENV infection. We used small interfering RNA-mediated knockdown (KD) and CRISPR-Cas9 knockout (KO) approaches, to investigate the role of CMPK2 in mouse and human cells. The results showed that CMPK2 was critical in DENV-induced antiviral cytokine release and mitochondrial oxidative stress and mitochondrial DNA release to the cytosol. The DENV-induced activation of Toll-like receptor (TLR)-9, inflammasome pathway, and cell migration was suppressed by CMPK2 depletion; however, viral production increased under CMPK2 deficiency. Examining mouse bone marrow-derived dendritic cells from interferon-alpha (IFN-α) receptor-KO mice and signal transducer and activator of transcription 1 (STAT1)-KO mice, we confirmed that CMPK2-mediated antiviral activity occurred in IFN-dependent and IFN-independent manners. In sum, CMPK2 is a critical factor in DENV-induced immune responses to determine innate immunity."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2021.102498"xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2021.102498"xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Huang C.Y."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Huang C.Y."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Wu C.H."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Wu C.H."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Ho L.J."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Ho L.J."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Hung L.F."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Hung L.F."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Lai J.H."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Lai J.H."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Chang Z.F."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Chang Z.F."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Ka S.M."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Ka S.M."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Wu D.W."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/author | "Wu D.W."xsd:string |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34142025 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |