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| http://purl.uniprot.org/citations/34146466 | http://www.w3.org/2000/01/rdf-schema#comment | "Ploidy variation is a cancer hallmark and is frequently associated with poor prognosis in high-grade cancers. Using a Drosophila solid-tumor model where oncogenic Notch drives tumorigenesis in a transition-zone microenvironment in the salivary gland imaginal ring, we find that the tumor-initiating cells normally undergo endoreplication to become polyploid. Upregulation of Notch signaling, however, induces these polyploid transition-zone cells to re-enter mitosis and undergo tumorigenesis. Growth and progression of the transition-zone tumor are fueled by a combination of polyploid mitosis, endoreplication, and depolyploidization. Both polyploid mitosis and depolyploidization are error prone, resulting in chromosomal copy-number variation and polyaneuploidy. Comparative RNA-seq and epistasis analysis reveal that the DNA-damage response genes, also active during meiosis, are upregulated in these tumors and are required for the ploidy-reduction division. Together, these findings suggest that polyploidy and associated cell-cycle variants are critical for increased tumor-cell heterogeneity and genome instability during cancer progression."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2021.05.017"xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/author | "Chang C.H."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/author | "Huang Y.C."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/author | "Bao H."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/author | "Chatterjee D."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/author | "Gong S."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/author | "Wang X.F."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/author | "Deng W.M."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/author | "Irianto J."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/author | "Yang S.A."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/author | "Portilla J.M."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/pages | "1976-1988.e4"xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/title | "Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model."xsd:string |
| http://purl.uniprot.org/citations/34146466 | http://purl.uniprot.org/core/volume | "56"xsd:string |
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