| http://purl.uniprot.org/citations/34156031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34156031 | http://www.w3.org/2000/01/rdf-schema#comment | "PDCD10, also known as CCM3, is a gene found to be associated with the human disease cerebral cavernous malformations (CCMs). PDCD10 forms a complex with GCKIII kinases including STK24, STK25, and MST4. Studies in C. elegans and Drosophila have shown a pivotal role of the PDCD10-GCKIII complex in maintaining epithelial integrity. Here, we found that mice deficient of Pdcd10 or Stk24/25 in the kidney tubules developed polyuria and displayed increased water consumption. Although the expression levels of aquaporin genes were not decreased, the levels of total and phosphorylated aquaporin 2 (Aqp2) protein in the apical membrane of tubular epithelial cells were decreased in Pdcd10- and Stk24/25-deficient mice. This loss of Aqp2 was associated with increased expression and membrane targeting of Ezrin and phosphorylated Ezrin, Radixin, Moesin (p-ERM) proteins and impaired intracellular vesicle trafficking. Treatment with Erlotinib, a tyrosine kinase inhibitor promoting exocytosis and inhibiting endocytosis, normalized the expression level and membrane abundance of Aqp2 protein, and partially rescued the water reabsorption defect observed in the Pdcd10-deficient mice. Our current study identified the PDCD10-STK-ERM signaling pathway as a potentially novel pathway required for water balance control by regulating vesicle trafficking and protein abundance of AQP2 in the kidneys."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.142838"xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Gao R."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Liu R."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Qian Y."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Song S."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Zheng X."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Han Z."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Wong J.J."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Alexander S.I."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Zhuang T."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Choi J.P."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Lu H.A."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/author | "Wu S.T."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/pages | "142838"xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/title | "Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting."xsd:string |
| http://purl.uniprot.org/citations/34156031 | http://purl.uniprot.org/core/volume | "6"xsd:string |