| http://purl.uniprot.org/citations/34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34158508 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks (DSBs) occurring within transcriptional active regions of the genome. The induction of DNA-RNA hybrids strongly affects the repair of these DSBs, but the nature of these structures and how they are formed remain poorly understood. Here we provide evidence that R loops, three-stranded structures containing DNA-RNA hybrids and the displaced single-stranded DNA (ssDNA) can form at sub-telomeric DSBs. These R loops are generated independently of DNA resection but are induced alongside two-stranded DNA-RNA hybrids that form on ssDNA generated by DNA resection. We further identified UPF1, an RNA/DNA helicase, as a crucial factor that drives the formation of these R loops and DNA-RNA hybrids to stimulate DNA resection, homologous recombination, microhomology-mediated end joining and DNA damage checkpoint activation. Our data show that R loops and DNA-RNA hybrids are actively generated at DSBs to facilitate DNA repair."xsd:string |
| http://purl.uniprot.org/citations/34158508 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-24201-w"xsd:string |
| http://purl.uniprot.org/citations/34158508 | http://purl.uniprot.org/core/author | "Grimstead J.W."xsd:string |
| http://purl.uniprot.org/citations/34158508 | http://purl.uniprot.org/core/author | "Baird D.M."xsd:string |
| http://purl.uniprot.org/citations/34158508 | http://purl.uniprot.org/core/author | "Ngo G.H.P."xsd:string |
| http://purl.uniprot.org/citations/34158508 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34158508 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34158508 | http://purl.uniprot.org/core/pages | "3849"xsd:string |
| http://purl.uniprot.org/citations/34158508 | http://purl.uniprot.org/core/title | "UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair."xsd:string |
| http://purl.uniprot.org/citations/34158508 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34158508 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34158508 |
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| http://purl.uniprot.org/uniprot/#_A0A024R7L5-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A059X4U2-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A059XAJ5-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A059XAL2-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A059XAL6-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A059XAM1-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A059XBJ1-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A059XBJ6-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A059XG67-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A059XG73-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A8A5YNF9-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |
| http://purl.uniprot.org/uniprot/#_A0A8A5YNG5-mappedCitation-34158508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34158508 |