| http://purl.uniprot.org/citations/34161768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34161768 | http://www.w3.org/2000/01/rdf-schema#comment | "Projection neuron subtype identities in the cerebral cortex are established by expressing pan-cortical and subtype-specific effector genes that execute terminal differentiation programs bestowing neurons with a glutamatergic neuron phenotype and subtype-specific morphology, physiology, and axonal projections. Whether pan-cortical glutamatergic and subtype-specific characteristics are regulated by the same genes or controlled by distinct programs remains largely unknown. Here, we show that FEZF2 functions as a transcriptional repressor, and it regulates subtype-specific identities of both corticothalamic and subcerebral neurons by selectively repressing expression of genes inappropriate for each neuronal subtype. We report that TLE4, specifically expressed in layer 6 corticothalamic neurons, is recruited by FEZF2 to inhibit layer 5 subcerebral neuronal genes. Together with previous studies, our results indicate that a cortical glutamatergic identity is specified by multiple parallel pathways active in progenitor cells, whereas projection neuron subtype-specific identity is achieved through selectively repressing genes associated with alternate identities in differentiating neurons."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2021.109269"xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Chen B."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Liu G."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Sestan N."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Qiu S."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Roberts J.M."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Finn T."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "McConnell S.K."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Gallardo D."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Katzman S."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Nehme A."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Tastad D."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Tsyporin J."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Huebner L."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/author | "Makhamreh A."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/pages | "109269"xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/title | "Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons."xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/34161768 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34161768 |