| http://purl.uniprot.org/citations/34166612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34166612 | http://www.w3.org/2000/01/rdf-schema#comment | "Cadherin extracellular domain 1 (EC1) mediates homophilic dimerization in adherens junctions. Conserved Trp2 and Trp4 residues in type II cadherins anchor the EC1 A strand intermolecularly in strand-swapped dimers. Herein, NMR spectroscopy is used to elucidate the roles of Trp2 and Trp4 in Cadherin-11 dimerization. The monomeric state, with the A strand and Trp side chains packed intramolecularly, is in equilibrium with sparsely populated partially and fully A-strand-exposed states, in which Trp2 (and Trp4, respectively) side-chain packing is disrupted. Exchange kinetics between the major state and the partially (fully) A-strand-exposed state is slow-intermediate (intermediate-fast). A separate very fast process exchanges ordered and random-coil BC-loop conformations with populations dependent on A-strand exposure and dimerization status. In addition, very slow processes connect the folded A-strand-exposed conformation to partially unfolded states, which may represent additional domain-swapping intermediates. The dimerization mechanism of type II cadherins is revealed as coupled folding and strand swapping."xsd:string |
| http://purl.uniprot.org/citations/34166612 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2021.06.006"xsd:string |
| http://purl.uniprot.org/citations/34166612 | http://purl.uniprot.org/core/author | "Honig B."xsd:string |
| http://purl.uniprot.org/citations/34166612 | http://purl.uniprot.org/core/author | "Shapiro L."xsd:string |
| http://purl.uniprot.org/citations/34166612 | http://purl.uniprot.org/core/author | "Palmer A.G."xsd:string |
| http://purl.uniprot.org/citations/34166612 | http://purl.uniprot.org/core/author | "Koss H."xsd:string |
| http://purl.uniprot.org/citations/34166612 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34166612 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/34166612 | http://purl.uniprot.org/core/pages | "1105-1115.e6"xsd:string |
| http://purl.uniprot.org/citations/34166612 | http://purl.uniprot.org/core/title | "Dimerization of Cadherin-11 involves multi-site coupled unfolding and strand swapping."xsd:string |
| http://purl.uniprot.org/citations/34166612 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/34166612 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34166612 |
| http://purl.uniprot.org/citations/34166612 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34166612 |
| http://purl.uniprot.org/uniprot/#_P55288-mappedCitation-34166612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34166612 |
| http://purl.uniprot.org/uniprot/#_Q8C7Q6-mappedCitation-34166612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34166612 |
| http://purl.uniprot.org/uniprot/Q8C7Q6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34166612 |
| http://purl.uniprot.org/uniprot/P55288 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34166612 |