| http://purl.uniprot.org/citations/34171296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34171296 | http://www.w3.org/2000/01/rdf-schema#comment | "In pathogenic mycobacteria, transcriptional responses to antibiotics result in induced antibiotic resistance. WhiB7 belongs to the Actinobacteria-specific family of Fe-S-containing transcription factors and plays a crucial role in inducible antibiotic resistance in mycobacteria. Here, we present cryoelectron microscopy structures of Mycobacterium tuberculosis transcriptional regulatory complexes comprising RNA polymerase σA-holoenzyme, global regulators CarD and RbpA, and WhiB7, bound to a WhiB7-regulated promoter. The structures reveal how WhiB7 interacts with σA-holoenzyme while simultaneously interacting with an AT-rich sequence element via its AT-hook. Evidently, AT-hooks, rare elements in bacteria yet prevalent in eukaryotes, bind to target AT-rich DNA sequences similarly to the nuclear chromosome binding proteins. Unexpectedly, a subset of particles contained a WhiB7-stabilized closed promoter complex, revealing this intermediate's structure, and we apply kinetic modeling and biochemical assays to rationalize how WhiB7 activates transcription. Altogether, our work presents a comprehensive view of how WhiB7 serves to activate gene expression leading to antibiotic resistance."xsd:string |
| http://purl.uniprot.org/citations/34171296 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2021.05.017"xsd:string |
| http://purl.uniprot.org/citations/34171296 | http://purl.uniprot.org/core/author | "Campbell E.A."xsd:string |
| http://purl.uniprot.org/citations/34171296 | http://purl.uniprot.org/core/author | "Darst S.A."xsd:string |
| http://purl.uniprot.org/citations/34171296 | http://purl.uniprot.org/core/author | "Lilic M."xsd:string |
| http://purl.uniprot.org/citations/34171296 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34171296 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/34171296 | http://purl.uniprot.org/core/pages | "2875-2886.e5"xsd:string |
| http://purl.uniprot.org/citations/34171296 | http://purl.uniprot.org/core/title | "Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7."xsd:string |
| http://purl.uniprot.org/citations/34171296 | http://purl.uniprot.org/core/volume | "81"xsd:string |
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