| http://purl.uniprot.org/citations/34180393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34180393 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal ankyrins cluster and link membrane proteins to the actin and spectrin-based cytoskeleton. Among the three vertebrate ankyrins, little is known about neuronal Ankyrin-R (AnkR). We report AnkR is highly enriched in Pv+ fast-spiking interneurons in mouse and human. We identify AnkR-associated protein complexes including cytoskeletal proteins, cell adhesion molecules (CAMs), and perineuronal nets (PNNs). We show that loss of AnkR from forebrain interneurons reduces and disrupts PNNs, decreases anxiety-like behaviors, and changes the intrinsic excitability and firing properties of Pv+ fast-spiking interneurons. These changes are accompanied by a dramatic reduction in Kv3.1b K+ channels. We identify a novel AnkR-binding motif in Kv3.1b, and show that AnkR is both necessary and sufficient for Kv3.1b membrane localization in interneurons and at nodes of Ranvier. Thus, AnkR regulates Pv+ fast-spiking interneuron function by organizing ion channels, CAMs, and PNNs, and linking these to the underlying β1 spectrin-based cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.66491"xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Burlingame A.L."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Nair S."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Oses-Prieto J.A."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Ogawa Y."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Xue M."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Rasband M.N."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Longley C.M."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Stevens S.R."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Cykowski M.D."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Arumanayagam A.S."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/author | "Teliska L.H."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/pages | "e66491"xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/title | "Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels."xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/34180393 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34180393 |
| http://purl.uniprot.org/citations/34180393 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34180393 |
| http://purl.uniprot.org/uniprot/#_A0A087WNU5-mappedCitation-34180393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34180393 |
| http://purl.uniprot.org/uniprot/#_A0A087WRP9-mappedCitation-34180393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34180393 |
| http://purl.uniprot.org/uniprot/#_A0A087WRU2-mappedCitation-34180393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34180393 |
| http://purl.uniprot.org/uniprot/#_D3Z5M4-mappedCitation-34180393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34180393 |