| http://purl.uniprot.org/citations/34197627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34197627 | http://www.w3.org/2000/01/rdf-schema#comment | "Brown and beige adipocytes dissipate energy by uncoupling protein 1 (UCP1)-dependent and UCP1-independent thermogenesis, which may be utilized to develop treatments against obesity. We have found that mRNA and protein expression of the alanine/serine/cysteine transporter-1 (ASC-1) was induced during adipocyte differentiation of human brown-prone deep neck and beige-competent subcutaneous neck progenitors, and SGBS preadipocytes. cAMP stimulation of differentiated adipocytes led to elevated uptake of serine, cysteine, and glycine, in parallel with increased oxygen consumption, augmented UCP1-dependent proton leak, increased creatine-driven substrate cycle-coupled respiration, and upregulation of thermogenesis marker genes and several respiratory complex subunits; these outcomes were impeded in the presence of the specific ASC-1 inhibitor, BMS-466442. Our data suggest that ASC-1-dependent consumption of serine, cysteine, and glycine is required for efficient thermogenic stimulation of human adipocytes."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.14155"xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Fischer-Posovszky P."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Shaw A."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Wabitsch M."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Kristof E."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Fesus L."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Csosz E."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Gyory F."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Arianti R."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Toth B.B."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Vamos A."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/author | "Vinnai B.A."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/pages | "2085-2098"xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/title | "ASC-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation."xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://purl.uniprot.org/core/volume | "595"xsd:string |
| http://purl.uniprot.org/citations/34197627 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34197627 |
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| http://purl.uniprot.org/uniprot/Q9NWI3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34197627 |