| http://purl.uniprot.org/citations/34214466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34214466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34214466 | http://www.w3.org/2000/01/rdf-schema#comment | "N-degron pathways are a set of proteolytic systems that target the N-terminal destabilizing residues of substrates for proteasomal degradation. Recently, the Gly/N-degron pathway has been identified as a new branch of the N-degron pathway. The N-terminal glycine degron (Gly/N-degron) is recognized by ZYG11B and ZER1, the substrate receptors of the Cullin 2-RING E3 ubiquitin ligase (CRL2). Here we present the crystal structures of ZYG11B and ZER1 bound to various Gly/N-degrons. The structures reveal that ZYG11B and ZER1 utilize their armadillo (ARM) repeats forming a deep and narrow cavity to engage mainly the first four residues of Gly/N-degrons. The α-amino group of the Gly/N-degron is accommodated in an acidic pocket by five conserved hydrogen bonds. These structures, together with biochemical studies, decipher the molecular basis for the specific recognition of the Gly/N-degron by ZYG11B and ZER1, providing key information for future structure-based chemical probe design."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2021.06.010"xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2021.06.010"xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Feng Q."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Feng Q."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Ma Z."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Ma Z."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Mi W."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Mi W."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Song G."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Song G."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/34214466 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |