| http://purl.uniprot.org/citations/34216540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34216540 | http://www.w3.org/2000/01/rdf-schema#comment | "Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but the biological implications of this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing the ability of CD4+ helper T cells (TH) to polarize into different functional fates. Deficiency in ornithine decarboxylase, a crucial enzyme for polyamine synthesis, results in a severe failure of CD4+ T cells to adopt correct subset specification, underscored by ectopic expression of multiple cytokines and lineage-defining transcription factors across TH cell subsets. Polyamines control TH differentiation by providing substrates for deoxyhypusine synthase, which synthesizes the amino acid hypusine, and mice in which T cells are deficient for hypusine develop severe intestinal inflammatory disease. Polyamine-hypusine deficiency caused widespread epigenetic remodeling driven by alterations in histone acetylation and a re-wired tricarboxylic acid (TCA) cycle. Thus, polyamine metabolism is critical for maintaining the epigenome to focus TH cell subset fidelity."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2021.06.007"xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Kaminski M.M."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Corrado M."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Yosef N."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Balabanov S."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Buescher J.M."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Pearce E.L."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Mittler G."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Villa M."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Weiss H.J."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Pearce E.J."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Baixauli F."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Puleston D.J."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Sanin D.E."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Grzes K.M."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Kabat A.M."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Edwards-Hicks J."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Field C.S."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Musa Y."xsd:string |
| http://purl.uniprot.org/citations/34216540 | http://purl.uniprot.org/core/author | "Flachsmann L."xsd:string |