| http://purl.uniprot.org/citations/34216545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34216545 | http://www.w3.org/2000/01/rdf-schema#comment | "Aneuploidy, an unbalanced number of chromosomes, is highly deleterious at the cellular level and leads to senescence, a stress-induced response characterized by permanent cell-cycle arrest and a well-defined associated secretory phenotype. Here, we use a Drosophila epithelial model to delineate the pathway that leads to the induction of senescence as a consequence of the acquisition of an aneuploid karyotype. Whereas aneuploidy induces, as a result of gene dosage imbalance, proteotoxic stress and activation of the major protein quality control mechanisms, near-saturation functioning of autophagy leads to compromised mitophagy, accumulation of dysfunctional mitochondria, and the production of radical oxygen species (ROS). We uncovered a role of c-Jun N-terminal kinase (JNK) in driving senescence as a consequence of dysfunctional mitochondria and ROS. We show that activation of the major protein quality control mechanisms and mitophagy dampens the deleterious effects of aneuploidy, and we identify a role of senescence in proteostasis and compensatory proliferation for tissue repair."xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2021.06.009"xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/author | "Joy J."xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/author | "Romao D."xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/author | "Milan M."xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/author | "Barrio L."xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/author | "Clemente-Ruiz M."xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/author | "Giakoumakis N.N."xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/author | "Santos-Tapia C."xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/pages | "2043-2058.e7"xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/title | "Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence."xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/34216545 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34216545 |
| http://purl.uniprot.org/citations/34216545 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34216545 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHH2-mappedCitation-34216545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34216545 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHI3-mappedCitation-34216545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34216545 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS6-mappedCitation-34216545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34216545 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS7-mappedCitation-34216545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34216545 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF86-mappedCitation-34216545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34216545 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6Y4-mappedCitation-34216545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34216545 |
| http://purl.uniprot.org/uniprot/#_D2NUH8-mappedCitation-34216545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34216545 |
| http://purl.uniprot.org/uniprot/#_E1JHD6-mappedCitation-34216545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34216545 |