| http://purl.uniprot.org/citations/34226299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34226299 | http://www.w3.org/2000/01/rdf-schema#comment | "miR-144-3p is aberrantly expressed in several types of human cancer and functions as a tumor suppressor by inhibiting metastasis. However, the clinical significance and biological function of miR-144-3p in colorectal adenocarcinoma (CRA) have yet to be elucidated. Here we reported that miR-144-3p expression level was significantly down-regulated in CRA tissues compared with matched noncancerous colorectal mucosae tissues. Low miR-144-3p expression was correlated with adverse clinicopathologic characteristics and poor prognosis of CRA patients. Cox regression analysis showed that low miR-144-3p expression was an independent risk factor for DFS and OS in CRA. In vitro and in vivo assays showed that miR-144-3p significantly inhibited proliferation, migration and invasion of CRA cells. In particular, miR-144-3p could suppress EMT process of CRA cells by regulating the cytoskeleton and EMT markers. Bioinformatics analysis indicated that EMT associated transcription factors ZEB1 and ZEB2 were potential targets of miR-144-3p, and miR-144-3p inhibited ZEB1 and ZEB2 expression and was negatively correlated with their expression in CRA. Finally, we confirmed that ZEB1 and ZEB2 down-regulation collaboratively mediated the inhibitory effect of miR-144-3p on proliferation, invasion and EMT of CRA cells. In conclusion, our study provided evidence that miR-144-3p could inhibit CRA cell proliferation, invasion and EMT by targeting ZEB1/2."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.203225"xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/author | "Huang Z."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/author | "Tang C."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/author | "Tang B."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/author | "Xiao B."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/author | "Dai H."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/author | "Lei X."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/pages | "17349-17369"xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/title | "miR-144-3p inhibited the growth, metastasis and epithelial-mesenchymal transition of colorectal adenocarcinoma by targeting ZEB1/2."xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/34226299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34226299 |
| http://purl.uniprot.org/citations/34226299 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34226299 |
| http://purl.uniprot.org/uniprot/#_B4DS26-mappedCitation-34226299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34226299 |
| http://purl.uniprot.org/uniprot/#_B2RBI8-mappedCitation-34226299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34226299 |
| http://purl.uniprot.org/uniprot/#_B4DGU2-mappedCitation-34226299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34226299 |
| http://purl.uniprot.org/uniprot/#_B4DSB8-mappedCitation-34226299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34226299 |
| http://purl.uniprot.org/uniprot/#_A0JLS9-mappedCitation-34226299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34226299 |
| http://purl.uniprot.org/uniprot/#_A0JP08-mappedCitation-34226299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34226299 |