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| http://purl.uniprot.org/citations/34233584 | http://www.w3.org/2000/01/rdf-schema#comment | "Supernumerary centrioles are frequently observed in diverse types of cancer cells. In this study, we investigated the mechanism underlying the generation of supernumerary centrioles during the M phase. We generated the TP53;PCNT;CEP215 triple knockout (KO) cells and determined the configurations of the centriole during the cell cycle. The triple KO cells exhibited a precocious separation of centrioles and unscheduled centriole assembly in the M phase. Supernumerary centrioles in the triple KO cells were present throughout the cell cycle; however, among all the centrioles, only two maintained an intact composition, including CEP135, CEP192, CEP295 and CEP152. Intact centrioles were formed during the S phase and the rest of the centrioles may be generated during the M phase. M-phase-assembled centrioles lacked the ability to organize microtubules in the interphase; however, a fraction of them may acquire pericentriolar material to organize microtubules during the M phase. Taken together, our work reveals the heterogeneity of the supernumerary centrioles in the triple KO cells. ."xsd:string |
| http://purl.uniprot.org/citations/34233584 | http://purl.org/dc/terms/identifier | "doi:10.1080/15384101.2021.1950386"xsd:string |
| http://purl.uniprot.org/citations/34233584 | http://purl.uniprot.org/core/author | "Rhee K."xsd:string |
| http://purl.uniprot.org/citations/34233584 | http://purl.uniprot.org/core/author | "Jung G.I."xsd:string |
| http://purl.uniprot.org/citations/34233584 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34233584 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
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| http://purl.uniprot.org/citations/34233584 | http://purl.uniprot.org/core/title | "Triple deletion of TP53, PCNT, and CEP215 promotes centriole amplification in the M phase."xsd:string |
| http://purl.uniprot.org/citations/34233584 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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