| http://purl.uniprot.org/citations/34234344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34234344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34234344 | http://www.w3.org/2000/01/rdf-schema#comment | "Peptide-chain elongation during protein synthesis entails sequential aminoacyl-tRNA selection and translocation reactions that proceed rapidly (2-20 per second) and with a low error rate (around 10-3 to 10-5 at each step) over thousands of cycles1. The cadence and fidelity of ribosome transit through mRNA templates in discrete codon increments is a paradigm for movement in biological systems that must hold for diverse mRNA and tRNA substrates across domains of life. Here we use single-molecule fluorescence methods to guide the capture of structures of early translocation events on the bacterial ribosome. Our findings reveal that the bacterial GTPase elongation factor G specifically engages spontaneously achieved ribosome conformations while in an active, GTP-bound conformation to unlock and initiate peptidyl-tRNA translocation. These findings suggest that processes intrinsic to the pre-translocation ribosome complex can regulate the rate of protein synthesis, and that energy expenditure is used later in the translocation mechanism than previously proposed."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-021-03713-x"xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-021-03713-x"xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Natchiar S.K."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Natchiar S.K."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Schacherl M."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Schacherl M."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Altman R.B."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Altman R.B."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Blanchard S.C."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Blanchard S.C."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Rundlet E.J."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Rundlet E.J."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Spahn C.M.T."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Spahn C.M.T."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Holm M."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Holm M."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Myasnikov A.G."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/author | "Myasnikov A.G."xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/34234344 | http://purl.uniprot.org/core/name | "Nature"xsd:string |