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http://purl.uniprot.org/citations/34237527http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34237527http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Advanced oxidation protein products (AOPPs), which are novel markers of oxidant-mediated protein damage, are prevalent in numerous diseases. We previously demonstrated that AOPPs act as a new class of pathogenic mediators in preeclampsia by causing trophoblast damage and dysfunction. Herein, we explored whether AOPPs could regulate the Nrf-2/ARE/HO-1 anti-oxidative pathway to facilitate the progression of preeclampsia.

Methods

To investigate the pathophysiology of preeclampsia, we evaluated the effects of AOPPs on trophoblast damage, apoptotic proteins, and Nrf-2/ARE/HO-1 anti-oxidative pathway expression, as well as their underlying mechanisms.

Results

AOPPs directly increased the expression of apoptotic proteins and significantly inhibited the expression of Nrf-2/ARE/HO-1 pathway in trophoblasts. Nrf-2 silencing aggravated the AOPPs-induced cell apoptosis in vitro by activating p53 and caspase cascade, whereas Nrf-2 overexpression had the opposite effect. Moreover, Nrf-2 exerted cytoprotective effects by increasing HO-1.

Discussion

These findings suggest that AOPPs induce trophoblast apoptosis by triggering p53 and caspase activation via inhibition of the Nrf-2/ARE/HO-1 anti-oxidative pathway. Hence, Nrf-2/ARE/HO-1 pathway activation plays a protective role in AOPPs-induced cell apoptosis; thus, holding potential as a therapeutic target against preeclampsia."xsd:string
http://purl.uniprot.org/citations/34237527http://purl.org/dc/terms/identifier"doi:10.1016/j.placenta.2021.06.008"xsd:string
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/author"Chen S."xsd:string
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/author"Chen Q."xsd:string
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/author"Hu H."xsd:string
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/author"Huang Q."xsd:string
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/author"Yin Q."xsd:string
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/author"Zhong M."xsd:string
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/name"Placenta"xsd:string
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/pages"1-8"xsd:string
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/title"AOPPs induce HTR-8/SVneo cell apoptosis by downregulating the Nrf-2/ARE/HO-1 anti-oxidative pathway: Potential implications for preeclampsia."xsd:string
http://purl.uniprot.org/citations/34237527http://purl.uniprot.org/core/volume"112"xsd:string
http://purl.uniprot.org/citations/34237527http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34237527
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