| http://purl.uniprot.org/citations/34241935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34241935 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone morphogenetic proteins (BMPs), members of the transforming growth factor-ß (TGF-ß) family, have been shown to contribute to embryogenesis and organogenesis during animal development. Relevant studies provide support for the following concepts: (a) BMP signals are evolutionarily highly conserved as a genetic toolkit; (b) spatiotemporal distributions of BMP signals are precisely controlled at the post-translational level; and (c) the BMP signaling network has been co-opted to adapt to diversified animal development. These concepts originated from the historical findings of the Spemann-Mangold organizer and the subsequent studies about how this organizer functions at the molecular level. In this Commentary, we focus on two topics. First, we review how the BMP morphogen gradient is formed to sustain larval wing imaginal disc and early embryo growth and patterning in Drosophila. Second, we discuss how BMP signal is tightly controlled in a context-dependent manner, and how the signal and tissue dynamics are coupled to facilitate complex tissue structure formation. Finally, we argue how these concepts might be developed in the future for further understanding the significance of BMP signaling in animal development."xsd:string |
| http://purl.uniprot.org/citations/34241935 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.397"xsd:string |
| http://purl.uniprot.org/citations/34241935 | http://purl.uniprot.org/core/author | "Shimmi O."xsd:string |
| http://purl.uniprot.org/citations/34241935 | http://purl.uniprot.org/core/author | "Tran N.V."xsd:string |
| http://purl.uniprot.org/citations/34241935 | http://purl.uniprot.org/core/author | "Montanari M.P."xsd:string |
| http://purl.uniprot.org/citations/34241935 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34241935 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/34241935 | http://purl.uniprot.org/core/pages | "198-212"xsd:string |
| http://purl.uniprot.org/citations/34241935 | http://purl.uniprot.org/core/title | "Regulation of spatial distribution of BMP ligands for pattern formation."xsd:string |
| http://purl.uniprot.org/citations/34241935 | http://purl.uniprot.org/core/volume | "251"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A1YJR7-mappedCitation-34241935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34241935 |
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