| http://purl.uniprot.org/citations/34244144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34244144 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1; also called PARK5) in the pathogenesis of Parkinson's disease (PD) has been controversial. Here, we find that the loss of UCHL1 destabilizes pyruvate kinase (PKM) and mitigates the PD-related phenotypes induced by PTEN-induced kinase 1 (PINK1) or Parkin loss-of-function mutations in Drosophila and mammalian cells. In UCHL1 knockout cells, cellular pyruvate production and ATP levels are diminished, and the activity of AMP-activated protein kinase (AMPK) is highly induced. Consequently, the activated AMPK promotes the mitophagy mediated by Unc-51-like kinase 1 (ULK1) and FUN14 domain-containing 1 (FUNDC1), which underlies the effects of UCHL1 deficiency in rescuing PD-related defects. Furthermore, we identify tripartite motif-containing 63 (TRIM63) as a previously unknown E3 ligase of PKM and demonstrate its antagonistic interaction with UCHL1 to regulate PD-related pathologies. These results suggest that UCHL1 is an integrative factor for connecting glycolysis and PD pathology."xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.abg4574"xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/author | "Choi S."xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/author | "Lee D."xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/author | "Cho E."xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/author | "Min S."xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/author | "Xu W.J."xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/author | "Ham S.J."xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/pages | "eabg4574"xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/title | "Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis."xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/34244144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34244144 |
| http://purl.uniprot.org/citations/34244144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34244144 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHQ8-mappedCitation-34244144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34244144 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHT3-mappedCitation-34244144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34244144 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI45-mappedCitation-34244144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34244144 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KH16-mappedCitation-34244144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34244144 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LH64-mappedCitation-34244144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34244144 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LHR7-mappedCitation-34244144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34244144 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LHS3-mappedCitation-34244144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34244144 |